Table 1 Characteristics of the study participants according to the ATN status
From: Exploring small non-coding RNAs as blood-based biomarkers to predict Alzheimer’s disease
Variable | A-T-N- participants | A+(T|N)+ participants | P value |
|---|---|---|---|
n | 95 | 95 | |
Age (years) | 69.2 (61.7, 76.2) | 76.6 (72.4, 80.1) | < 0.001*** |
Women [N (%)] | 46 (48.0) | 46 (48.0) | 1.000 |
Body mass index (kg/m2) | 27.2 (24.6, 29.2) | 25.5 (23.5, 28.5) | 0.036* |
APOE ε4 carriers [N (%)] | 13 (13.7) | 58 (61.1) | < 0.001*** |
Education (years) | 8 (6, 11) | 8 (6, 11) | 0.642 |
Smoking [N (%)] | |||
Never | 65 (68.4) | 67 (70.5) | 0.880 |
Former | 18 (18.9) | 22 (23.2) | 0.584 |
Current | 12 (12.6) | 6 (6.3) | 0.239 |
Medication [N (%)] | |||
Antidepressant and anxiolytic | 56 (58.9) | 32 (33.7) | < 0.001*** |
Antihypertensive | 33 (34.7) | 39 (41.1) | 0.480 |
Statins | 24 (25.3) | 28 (29.5) | 0.617 |
Other lipid-lowering drugs | 6 (6.3) | 7 (7.4) | 1.000 |
MMSE at baseline (score) | 27 (26, 29) | 25 (24, 27) | < 0.001*** |
A [N (%)] | 1 (1.1) | 95 (100.0) | < 0.001*** |
T [N (%)] | 0 (0.0) | 92 (96.8) | < 0.001*** |
N [N (%)] | 0 (0.0) | 67 (70.5) | < 0.001*** |
Follow-up (years) | 3.1 (2.2, 4.0) | 1.7 (1.0, 2.8) | < 0.001*** |
Conversion to AD [N (%)] | 5 (5.3) | 68 (71.6) | < 0.001*** |