Table 5 The inflammatory regulation of IFN-I signaling in the PI3K/AKT pathway
From: The crucial regulatory role of type I interferon in inflammatory diseases
Study | Types of IFN-I | Target of action | Stimuli | Experimental models | Effect | Diseases |
|---|---|---|---|---|---|---|
Guiducci et al. 2008 [190] | IFN-α and IFN-β | PI3K | PI3K inhibitor | Primary human pDCs | Pro-and anti-inflammatory | Not given |
Ding et al. 2021 [191] | IFN-α | IFN-α | IFN-α-NA | pDCs from C57BL/6 mice | Anti-inflammatory | SLE |
Gairhe et al. 2021 [192] | IFN-α and IFN-β | AKT | CAV1 gene loss | Fibroblasts and serum from PAH patients, and mice | Pro-inflammatory | PAH |
Matsumoto et al. 2009 [193] | IFN-α | mTOR | Rapa and AKT inhibitor | Human hepatocyte cells | Anti-inflammatory | Hepatitis C |