From: The crucial regulatory role of type I interferon in inflammatory diseases
Study | Types of IFN-I | Target of action | Stimuli | Experimental models | Effect | Diseases |
---|---|---|---|---|---|---|
Veenhuis et al. 2017 [96] | IFN-α and IFN-β | TLR 7 | HIV | Serum samples from HIV patients | Anti-inflammatory | HIV |
Yang et al. 2016 [97] | IFN-β | TLR 3 and TLR 7 | Enteric viruses | BALB/c mice | Anti-inflammatory | Colitis |
Sekheri et al. 2022 [98] | IFN-β | TLR 9 | ALX/FPR2 | Human neutrophils | Anti-inflammatory | ARDS |
Allen et al. 2021 [99] | IFN-α | TLR 7 | HIV | PBMCs from SLE patients | Anti-inflammatory | SLE |
Chang MY et al. 2017 [100] | IFN-β | TLR 3 or TLR 4 | LPS and versican | Transgenic mice | Anti-inflammatory | Bacterial infection |
Dhariwala et al. 2017 [101] | IFN-β | TLR 7 | Yersinia pestis | C57BL/6 mice | Anti-inflammatory | Bacterial infection |
Auger et al. 2017 [102] | IFN-β | IRF 3 and IRF 7 | Streptococcus suis Serotype 2 | C57BL/6 mice | Duality | Bacterial infection |
Cordoba-David et al. 2022 [103] | IFN-α and IFN-β | IRF 3 | LPS | mouse MCT cells | Anti-inflammatory | Nephritis |
Artusa et al. 2022 [104] | IFN-β | IRF 3 | Coffee extracts | THP-1 cells | Anti-inflammatory | Not given |
Zhou et al. 2020 [105] | IFN-β | IRF 3 | GTD | C57BL/6 mice | Anti-inflammatory | Viral infection |
Fritsch et al. 2022 [106] | IFN-β | IRF 3 | CCI or sham injury | C57BL/6 mice | Pro-inflammatory | TBI |
Huang et al. 2022 [107] | IFN-β | IRF 3 | Polβ | MEFs | Pro-inflammatory | Cancer |
Onsa-Ard et al. 2022 [108] | IFN-β | IRF 3 | RRBE | RAW 264.7 macrophages | Anti-inflammatory | Not given |
Liu et al. 2022 [109] | IFN-β | IRF 3 | RNF 5 | Human corneal epithelial cells | Pro-inflammatory | Viral infection |
Wu et al. 2019 [110] | IFN-α and IFN-β | IRF 7 | IRF 7 KO | C57BL/6 mice and skin tissue from a patient with SSc | Pro-inflammatory | SSc |
He et al. 2019 [111] | IFN-α and IFN-β | IRF 7 | Papain or IL-33 | C57BL/6 mice | Pro-inflammatory | Allergic airway inflammation |
Zhou et al. 2015 [112] | IFN-α and IFN-β | IRF 7 | AIP | HEK293T cells | Pro-inflammatory | Viral infection |
Hu et al. 2018 [113] | IFN-α and IFN-β | IRF 7 | High glucose | THP-1 cells | Pro-inflammatory | Diabetes |
Ren et al. 2016 [114] | IFN-α and IFN-β | IRF 7 | LPS or virus | IFNAR ± mice | Anti-inflammatory | Viral infection |
Trevejo-Nunez et al. 2021 [115] | IFN-α and IFN-β | IRF 7 | Regnase-1 | C57BL/6 mice | Anti-inflammatory | Bacterial infection |
Valaperti et al. 2014 [116] | IFN-α and IFN-β | RIG-I | CAP | CAP (−/−) mice | Anti-inflammatory | Myocarditis |
Villamayor et al. 2023 [117] | IFN-α | RIG-I | IFI 6 | 293 T and MDCK cells | Pro-inflammatory | Viral infection |
Simpson et al. 2017 [118] | IFN-α and IFN-β | RIG-I and RLR | IPS-1 | C57BL/6 mice | Anti-inflammatory | Viral infection |
Zheng et al. 2022 [119] | IFN-β | RIG-I-MAVS | NSP5 and N proteins of SARS-CoV-2 | HEK‐293 T, HeLa, and Vero E6 cells | Pro-inflammatory | Viral infection |
Han et al. 2021 [120] | IFN-β | RIG-I/MDA5-MAVS | SARS-CoV-2 ORF9b | HEK‐293 T, HeLa, and Vero E6 cells | Pro-inflammatory | Viral infection |
Zheng et al. 2020 [121] | IFN-β | RIG-I/MDA5-MAVS | SARS-CoV-2 M protein | HEK293, HEK293T, HeLa, and Vero cells | Pro-inflammatory | Viral infection |
Deng et al. 2023 [122] | IFN-β | RIG-I/MDA5-MAVS | SARS-CoV-2 NSP7 | HEK293T, HeLa, Vero, and HK-2 cells | Pro-inflammatory | Viral infection |
Deng et al. 2023 [123] | IFN-β | RIG-I/ MDA5-MAVS | SARS-CoV-2 NSP8 | HEK293T, HeLa, Vero, HK-2, and L929 cells | Pro-inflammatory | Viral infection |
Liu et al. 2018 [124] | IFN-β | MAVS | TRIM21 | BALB/c mice | Anti-inflammatory | Viral infection |
Gutierrez-Merino et al. 2020 [125] | IFN-α and IFN-β | MAVS | LAB | BMDMs, PBMCs and THP-1 cells | Anti-inflammatory | Bacterial infection |
Killarney et al. 2023 [126] | IFN-β | MAVS | Chemotherapy | A375 and Colo205 cells | Anti-inflammatory | Not given |
Huang et al. 2022 [127] | IFN-β | MAVS | Sorafenib | 293 T cells | Anti-inflammatory | Not given |
Han et al. 2022 [128] | IFN-β | MAVS | RNF114 | BALB/c mice | Pro-inflammatory | Viral infection |
Pons et al. 2021 [129] | IFN-α and IFN-β | cGAS | CDT | HeLa cells and mouse embryonic fibroblasts | Anti-inflammatory | Viral infection |
Hsin et al. 2021 [130] | IFN-β | STING | Hepsin | human hepatocytes and HEK293T cells | Pro-inflammatory | Viral infection |
Fischer et al. 2020 [131] | IFN-α and IFN-β | cGAS/STING | Cutibacterium | THP-1 cells | Anti-inflammatory | Bacterial infection |
Vail et al. 2021 [132] | IFN-β | cGAS/STING | Rhodococcus equi | BMDMs | Pro-inflammatory | Bacterial infection |
Wang et al. 2022 [133] | IFN-α and IFN-β | RIPK1-TBK1 | Caspase 8 | C57BL/6 mice | Anti-inflammatory | Viral infection |
Torre et al. 2017 [134] | IFN-α and IFN-β | TRIM 25 | USP 15 | C57BL/6 mice | Anti-inflammatory | Neuroinflammation |
Li et al. 2022 [135] | IFN-α | SLC15A4 | miR-31-5p | Peripheral blood sample from SLE patients | Anti-inflammatory | SLE |