The crucial regulatory role of type I interferon in inflammatory diseases

Ji, Ling; Li, Tianle; Chen, Huimin; Yang, Yanqi; Lu, Eryi; Liu, Jieying; Qiao, Wei; Chen, Hui

doi:10.1186/s13578-023-01188-z

Cell & Bioscience

Table 2 The inflammatory regulation of IFN-I signaling in the JAK/STAT pathway

From: The crucial regulatory role of type I interferon in inflammatory diseases

Study	Types of IFN-I	Target of action	Stimuli	Experimental models	Effect	Diseases
Dean et al. 2021 [56]	IFN-I	IFN-I	COVID-19	Peripheral blood of COVID-19 patients	Duality	Viral infection
Nocito et al. 2020 [57]	IFN-α	IFN-α	Captopril	MRL/lpr and MRL/wt female mice	Anti-inflammatory	SLE
Kitamura et al. 2020 [58]	IFN-α	IFN-α	Experimental radiation	C57BL/6 mice	Pro-inflammatory	Esophagitis
Fernandez-Sendin et al. 2020 [59]	IFN-α	IFN-α	Apolipoprotein AI mimetic peptide L37pA	C57BL/6 mice	Anti-inflammatory	Viral infection
Chen et al. 2022 [60]	IFN-α	IFN-α	A. cinnamomea	BHK-21 cells	Anti-inflammatory	Viral infection
Zhang et al. 2022 [61]	IFN-β	IFN-β	PON1	PAM	Pro-inflammatory	Viral infection
Li et al. 2020 [62]	IFN-β	IFN-β	MiR-30a	HeLa cells and 293 T cells	Pro-inflammatory	Viral infection
Jang et al. 2018 [63]	IFN-β	IFN-β	Enhanced IFN-β	Human tissue from a patient with sinusitis	Pro-inflammatory	Sinusitis
Cook et al. 2019 [64]	IFN-α and IFN-β	IFN-α and IFN-β	CHIKV	C57BL/6 mice	Anti-inflammatory	Viral infection
Lei et al. 2021 [65]	IFN-α and IFN-β	IFN-β	NRF2	mtDNA mutant mice	Pro-inflammatory	Not given
Arimori et al. 2013 [66]	IFN-α and IFN-β	IFNAR	IFNAR KO	IFNAR KO mouse models	Pro-inflammatory	Viral infection
Sontheimer et al. 2017 [67]	IFN-α and IFN-β	IFNAR	UVB and IFNAR KO	IFNAR KO mouse models	Pro-inflammatory	SLE
Ansar et al. 2021 [68]	IFN-α	IFNAR	RS	BAL from mice	Anti-inflammatory	Viral infection
Cagliani et al. 2019 [69]	IFN-α	IFNAR	IFNAR1-Ab	C57BL6 mice	Anti-inflammatory	HS
D'Souza et al. 2021 [70]	IFN-α and IFN-β	IFNAR	MO-IFN	C57BL/6 mice	Pro-inflammatory	Not given
Chan et al. 2020 [71]	IFN-α and IFN-β	IFNAR	Activation of IFN/ IFNAR axis	Mouse primary adipocytes	Pro-inflammatory	Obesity
Minayoshi et al. 2018 [72]	IFN-α and IFN-β	IFNAR	Man-HSA(D494N)-IFNα2b	C57BL/6 mice	Anti-inflammatory	Hepatitis
Tanaka et al. 2012 [73]	IFN-α and IFN-β	STAT1	Damaged STAT1	Gingival tissue samples	Pro-inflammatory	Periodontitis
Nataraja et al. 2022 [74]	IFN-α	STAT1	GILZ	C57BL/6 mice	Anti-inflammatory	SLE
Chen et al. 2022 [75]	IFN-α	STAT1	Menthone	CIA mouse models	Anti-inflammatory	RA
Hu et al. 2022 [76]	IFN-β	STAT1	RUNX1	A549 cells	Anti-inflammatory	Viral infection
Yang et al. 2020 [77]	IFN-α and IFN-β	STAT1	hsa_circ_0060450	Peripheral blood of T1DM patients and healthy controls	Anti-inflammatory	T1DM
Gothe et al. 2022 [78]	IFN-α	STAT2	STAT2 deficiency	pluripotent stem cell-derived macrophages	Pro-inflammatory	Not given
Wilson et al. 2019 [79]	IFN-α and IFN-β	STAT2	S. typhimurium	C57BL/6 mice	Pro-inflammatory	Bacterial infection
Shen et al. 2020 [80]	IFN-β	STAT2	PCV3 Cap	HEK 293 T and PK15 cells	Pro-inflammatory	Viral infection
Kozela et al. 2010 [81]	IFN-β	STAT3	CBD	BV-2 murine microglial cell line	Anti-inflammatory	Not given
Racicot et al. 2016 [82]	IFN-β	STAT3	Upregulated STAT3	Human trophoblasts SW.71 and C57BL/6 mice	Pro-inflammatory	Placental inflammation
Febvre-James et al. 2018 [83]	IFN-β	JAK	Ruxolitinib	PBMCs	Anti-inflammatory	Not given
Klopfenstein et al. 2021 [84]	IFN-β	JAK and STAT	MRSA	C57BL/6 mice	Pro-inflammatory	Bacterial infection
Hadjadj et al. 2020 [85]	IFN-α and IFN-β	JAK and STAT1	COVID-19	sera from COVID-19 patients	Anti-inflammatory	Viral infection
Stefan et al. 2017 [86]	IFN-α and IFN-β	IL-10R	S. typhimurium	C57BL/6 mice	Pro-inflammatory	Salmonella colitis
Qu et al. 2015 [87]	IFN-α and IFN-β	MCPIP-1 and miR-146a	IFN-α and IFN-β	THP-1 cells	Pro-inflammatory	SLE
Zhang et al. 2015 [88]	IFN-α and IFN-β	ISG15	USP18	Human blood sample cells	Pro-inflammatory	Not given

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ISSN: 2045-3701

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