The crucial regulatory role of type I interferon in inflammatory diseases

Cell & Bioscience

Table 1 Ligands and receptors induce type I interferons

Ligands	Receptor	Receptor location	References
RNA	RIG-I	Cytosol	[34]
RNA	MDA5	Cytosol	[35]
AT-rich DNA	RNA polymerase III	Cytosol	[36]
DNA	DAI	Cytosol	[37]
DNA	DEXD/H box	Cytosol	[38]
DNA	cGAS	Cytosol	[31]
Bacterial/Virus	NOD1/2	Cytosol	[39]
Bacterial	TLR 4	Cell-surface	[40]
Virus	TLR 2	Cell-surface	[41]
Double-stranded RNA	TLR 3	Endosomal	[42]
Single-stranded RNA	TLR 7/8	Endosomal	[43]
Unmethylated CpG DNA	TLR 9	Endosomal	[44]

ISSN: 2045-3701