Table 1 KEGG pathway analysis has identified significant pathways that are different between KO and WT after CCl4-induced liver injury
Pathway description | Observed gene count | FDR | Matching proteins in the data |
|---|---|---|---|
PPAR signaling pathway | 9 | 7.56E-06 | ACSL3,ACSL4,APOA2,APOA5,CYP7A1,CYP8B1,FABP4,FABP5,LPL |
Metabolic pathways | 27 | 0.00416 | ACSL3,ACSL4,AGXT2L1,ALAS1,ALDH3A2,AMDHD1,ATP6V0C,B3GALT1,CSAD,CYP2E1,CYP7A1,CYP8B1,GCLC,GLUL,HAL,HMGCR,HSD3B2,HSD3B7,HYI,ISYNA1,LPIN1,LPIN2,MOCS1,OAT,RRM2,SPHK2,SQLE |
Protein processing in endoplasmic reticulum | 9 | 0.00416 | DNAJC3,HSP90AA1,HSP90B1,HSPA5,HYOU1,PDIA3,PDIA4,SSR3,SYVN1 |
Bile secretion | 6 | 0.00453 | ABCG5,ABCG8,CYP7A1,HMGCR,NR0B2,SLC10A2 |
Amoebiasis | 7 | 0.00506 | CD14,COL1A1,COL1A2,COL3A1,COL4A1,COL5A3,IL1R1 |
ECM-receptor interaction | 6 | 0.00897 | COL1A1,COL1A2,COL3A1,COL4A1,COL5A3,SPP1 |
Protein digestion and absorption | 6 | 0.00897 | COL1A1,COL1A2,COL3A1,COL4A1,COL5A3,SLC3A1 |
Platelet activation | 7 | 0.0104 | COL1A1,COL1A2,COL3A1,COL5A3,FGA,FGB,FGG |
Primary bile acid biosynthesis | 3 | 0.0181 | CYP7A1,CYP8B1,HSD3B7 |
PI3K-Akt signaling pathway | 11 | 0.0181 | CDKN1A,COL1A1,COL1A2,COL3A1,COL4A1,COL5A3,HSP90AA1,HSP90B1,IL6R,NR4A1,SPP1 |
Glutathione metabolism | 4 | 0.0355 | GCLC,GSTA2,GSTM4,RRM2 |
Transcriptional mis-regulation in cancer | 7 | 0.0355 | CD14,CDKN1A,CEBPA,CEBPE,ID2,TMPRSS2,ZBTB16 |
Glycerolipid metabolism | 4 | 0.047 | ALDH3A2,LPIN1,LPIN2,LPL |