Fig. 6
Representative EM images reveal more MDVs and mitophagy in Fkbp51 KO liver after CCl4 injury. A ER expansion (red arrow) and B damaged mitochondria with incomplete membranes were observed more often in WT. Mitochondrial derived vesicles (MDV) were found in both WT (B, C) and KO (E, F, K), but more occurrence was found in KO. D Normal ER in KO with laminated bodies (LB) formed inside mitochondria. E Normal ER and dense particles observed inside mitochondria with multiple MDVs inside and at border of mitochondria. F Lysosome close to MDVs, and ER expansion (arrow) was occasionally observed around damaged mitochondria in KO. G Lysosome with a dense laminated body. H Laminated bodies with damaged granule bodies. I LB within lysosome with. J, K More mitophagy was observed in KO and representative mitophagosomes are indicated by the red arrows. L Mitochondria, ER, and LB in close contact during clearance of mitochondrial debris. Key: WT, wild type; KO, Fkbp51 KO; ER, endoplasmic reticulum; M, mitochondria; MDV, mitochondrial derived vesicles; LB, laminated bodies; L, lysosome