Fig. 5

Liver mitochondria are larger in Fkbp51 KO mice than in WT. A Representative EM photomicrographs of WT and KO liver mitochondria with or without CCl₄ treatment. B, C Mitochondrial size (area) quantification demonstrated that Fkbp51 KO mitochondria are larger in both control and CCl₄ conditions, although no differences in mitochondrial number were detected. Quantifications are from random representative microphotographs measuring 250–300 mitochondria. p values were determined by two-way ANOVA with the statistical significance labeled as follows: *as p < 0.05, *** as p < 0.001. D Representative EM photomicrographs depict ER expansion in WT following CCl₄ treatment. Key: WT, wild type; KO, Fkbp51 KO; Nu, nucleus; ER, endoplasmic reticulum