Fig. 5

Construction of prognostic prediction model. A Over-representation analysis of 39 FDGs in the MSigDB gene sets, comparing the enrichment results of primary MESO with bone metastatic tumors. B The univariate Cox regression analysis between gene expression and overall survival (OS). C The expression levels of PLAAT4, ADH1B, CDC20, CKS2, JPT1 and LDLR, the genes selected to be included in the risk score calculation, in the low-risk group and high-risk group of the all, train and test cohorts. The all cohort referred to the entire TCGA cohort of MESO patients from which the train and test were randomly separated at the ratio of 6:4. D The forest plots showed the univariate and multivariate Cox regression analyses for clinical parameters (age, gender, stage, bone metastasis and distant metastasis) and risk score. E The clinical parameters’ differences between the low-risk group and high-risk group. F The comparison of survival outcomes (alive or dead) between the low-risk group and high-risk group with chi-square test. G The gene set enrichment analysis (GSEA) of the high-risk group and the low-risk group, based on the hallmark gene sets