Fig. 3

Global transcriptomic analyses revealed the differences between Nell-1^+/6R mouse hippocampus and their WT counterparts. A The heatmap visualizes the Nell-1-responsive differential expressed genes (DEGs) in the mouse hippocampus. N  = 6 (3 males [labeled as blue at the bottom] and 3 females [labeled as pink at the bottom]) for each genotype. B The top 20 of the downregulated DEGs enriched pathways with a P-value less than 0.01. C The upregulated DEGs enriched pathways with a P-value less than 0.01. D Alternative splicing (AS) analysis results with a P-value less than 0.05. The alternative splicing event with a false discovery rate of less than 0.05 is highlighted in red