Fig. 1
From: Ferroptosis in cardiovascular diseases: role and mechanism
Regulatory mechanism of ferroptosis. The unstable iron pool oxidizes the PUFA on the cell membrane through the Fenton reaction and eventually leads to ferroptosis. GPX4 reduces PL-OOH to PL-OH in the presence of GSH and thus inhibits ferroptosis. DHODH in mitochondria and FSP1 reduce PL-OOH to PL-OH by providing CoQH2. GTP directly inhibits PUFA oxidation by increasing BH4