Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas

Table 1 Exosome miRNAs in OPBG-DIPG002 and OPBG-GBM002 single-cell-derived clones

Cell line	Single-cell-derived clone	exo-miRNAs	Target gene	Protein name	References
OPBG-DIPG002	1C5	hsa-mir-200c-3p	CRKL	CrkL	[24]
			FLNA	FLNA	[25]
			FN1	FN	[26]
			GLI3	GLI3	[27]
			NTRK2	NTRK2	[28]
			PTPRZ1	PTPRZ	[29]
			TUBB2A	TUBB2A	[30]
			VEGFA	VEGF-a	[31]
			DDIT4	DDIT4	[32]
	2B4	hsa-mir-582-5p	MNX1	MNX1	[33]
			RAC1	RAC1	[34]
			NR2F2	NR2F2	[35]
			TBX20	TBX20	[36]
		hsa-mir-885-5p	CTNNB1	β-Catenin	[37]
			PAFAH1B1	PAFAH1B1	[38]
			RAC1	RAC1	[34]
			MNX1	MNX1	[33]
		hsa-miR-887-3p	–	–	–
OPBG-GBM002	5E2	hsa-mir-877-5p	MAPK8	MAPK8	[39]
			NR2F2	NR2F2	[35]
			AMOTL2	AmotL2	[40]
			NDE1	NudE	[41]
			TUBB2B	TUBB2B	[42]
		hsa-miR-203a	–	–	–
	1D3	hsa-mir-22-3p	NTRK2	NTRK2	[28]
			PEX5	PEX5	[43]
			FUBP1	FUSE-binding protein 1	[44]
			DDIT4	DDIT4	[32]
		hsa-mir-376a-3p	FOXG1	FOXG1	[45]
			PDS5A	PDS5 homolog A	[46]
			AMOTL2	AmotL2	[40]
		hsa-miR-572	–	–	–

Table of exclusive exo-miRNAs found in the clones and their predicted target genes involved in migration and/or invasion processes

ISSN: 2045-3701