Fig. 4

Oxidative stress-induced changes in synuclein interactome. A Comparative functional profile of control (con.) and stress (str.) induced cells, in the domains of biological process (BP), molecular function (MF) and cellular component (CC) using ToppCluster. An ‘abstracted’ network option was chosen to generate a Cytoscape-compatible network, containing the top ten enriched terms. Some of the specific terms are labeled in the figure. B A map of three posttranslational modifications (Acetylation, methylation, and phosphorylation) identified by mass spectrometry analysis, in both control and stress-dependent interactome of synuclein protein