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Fig. 1 | Cell & Bioscience

Fig. 1

From: The key cellular senescence related molecule RRM2 regulates prostate cancer progression and resistance to docetaxel treatment

Fig. 1

Analysis of cellular senescence-associated core genes in prostate cancer. A Differential expression analysis of cellular senescence-related genes (SRGs) between tumor tissues and adjacent non-tumor tissues. The heatmap displays the fold change in gene expression, with upregulated genes marked in red and downregulated genes marked in blue. B Gene Set Enrichment Analysis (GSEA) showing the enrichment of differentially expressed genes (DEGs) in pathways such as the (TCA cycle). The enrichment score and nominal P-value are provided. C Cox-regression analysis results demonstrating the association between three cellular SRGs and overall survival (OS) in prostate cancer (PCa) cases. The hazard ratio (HR) and P-value are shown. D Kaplan–Meier survival analysis illustrating the association between ten cellular aging-associated genes and progression-free survival (PFS) in PCa cases. The log-rank P-value and hazard ratio (HR) are provided

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Cell & Bioscience

ISSN: 2045-3701

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