From: The impact of the gut microbiome on tumor immunotherapy: from mechanism to application strategies
Tumor type | Number of included patients | Immunotherapy treatment | Favorable clinical outcomes | Unfavorable clinical outcomes | References |
---|---|---|---|---|---|
NSCLC | 65 | ICB: αPD-1 mAb; αPD-L1 mAb; αCTLA-4 mAb | Ruminococcus; Akkermansia; Faecalibacterium |  | [89] |
Hepatocellular carcinoma (HCC) | 11 | ICB: αCTLA-4 mAb; αPD-L1 mAb | Akkermansia | Enterobacteriaceae | [90] |
Lung cancer | 46 | ICB: αPD-1 mAb |  | Fusobacterium | [91] |
Advanced hepatobiliary cancers | 65 | ICB: αPD-1 mAb | Lachnospiraceae bacterium-GAM79; Alistipes sp. Marseille-P5997; Ruminococcus calidus; Erysipelotichaceae bacterium-GAM147 | Veillonellaceae | [92] |
NSCLC | 30 | ICB: αPD-1 mAb; αPD-L1 mAb |  | Gammaproteobacteria | [93] |
CRC | 39 | Chemotherapy alone (oxaliplatin or capecitabine), or combined with ACT | Bifidobacterium; Lactobacillus; Enterococcus | Dialister pneumosintes; Escherichia coli; Lactobacillus reteri; Streptococcus mutans; Enterococcus faecium; Streptococcus gordonii; Veillonella atypica; Granulicatella sp.; Trchuris trichiura | [94] |
Advanced HCC | 8 | ICB: αPD-1 mAb (nivolumab) | Citrobacter freundii; Azospirillum sp.; Enterococcus durans; Akkermansia; |  | [95] |
Melanoma | 77 | ICB: αCTLA-4 mAb and αPD-1 mAb combined |  | Bacteroides intestinalis | [96] |
NSCLC | 88 | ICB: αPD-1 mAb |  | Helicobacter pylori | [97] |
NSCLC | 75 | ICB: αPD-1 mAb | Streptococcus |  | [98] |
NSCLC | 69 | ICB: αPD-1 mAb; αPD-L1 mAb | Phascolarctobacterium | Dialister | [99] |
Lung cancer | 34 | ICBs | Clostridiales | Rikenellaceae | [100] |
B-cell non-Hodgkin lymphoma | 51 | Immunochemotherapy | Dorea formicigenerans; Faecalibacterium prausnitzii | Â | [101] |
Metastatic melanoma | 130 | ICB: αPD-1 mAb; αPD-L1 mAb; αCTLA-4 mAb; ICB combination | Faecalibacterium; Ruminococcaceae; Barnesiella intestinihominis |  | [102] |
NSCLC | 11 | ICB: αPD-1 mAb | Akkermansia muciniphila; Rikenellaceae; Bacteroides; Peptostreptococcaceae; Mogibacteriaceae; Clostridiaceae |  | [103] |
Metastatic renal cell carcinoma (mRCC) | 21 | ICB: αPD-1 mAb | Akkermansia muciniphila |  | [104] |
NSCLC | 17 | ICB: αPD-1 mAb | Lactobacillus; Clostridium; Syntrophococcus | Bilophila; Sutterella; Parabacteroides | [105] |
NSCLC | 37 | ICB: αPD-1 mAb | Alistipes putredinis; Bifidobacterium longum; Prevotella copri |  | [106] |
HCC | 8 | ICB: αPD-1 mAb | Akkermansia muciniphila; Ruminococcaceae spp. |  | [107] |
Melanoma | 27 | ICB: αPD-1 mAb; αPD-L1 mAb; αCTLA-4 mAb; ICB combination | Faecalibacterium prausnitzii; Coprococcus eutactus; Prevotella stercorea; Streptococcus sanguinis; Streptococcus anginosus; Lachnospiraceae bacterium | Bacteroides ovatus; Bacteroides dorei; Bacteroides massiliensis; Ruminococcus gnavus; Blautia producta | [108] |
Melanoma | 112 | ICB: αPD-1 mAb | Ruminococcaceae family |  | [18] |
Metastatic melanoma | 42 | ICB: αPD-1 mAb | Bifidobacterium longum; Collinsella aerofaciens; Enterococcus faecium |  | [72] |
Gastrointestinal cancer | 74 | ICB: αPD-1 mAb; αPD-L1 mAb | Prevotella; Ruminococcaceae; Lachnospiraceae |  | [109] |
Thoracic neoplasms | 42 | ICB: αPD-1 mAb | Akkermansiaceae; Enterococcaceae; Enterobacteriaceae; Carnobacteriaceae; Clostridiales Family XI bacterial families |  | [110] |
Melanoma | 94 | ICB: αPD-1 mAb | Actinobacteria phylum; Lachnospiraceae; Ruminococcaceae; Lachnospiraceae spp.; Streptococcaceae spp. |  | [111] |
NSCLC | 294 | ICB: αPD-1 mAb | Bifidobacterium; Clostridium butyricum; lactic acid bacteria |  | [112] |
NSCLC | 21 | ICB combined with chemotherapy | Bifidobacterium; Escherichia; Sarterella | Â | [113] |
HCC | 35 | ICB: αPD-1 mAb | Ruminococcus |  | [114] |
Metastatic castrate resistant prostate cancer (mCRPC) | 23 | ICB combined with enzalutamide | Streptococcus salivarius | Akkermansia muciniphila; Collinsella aerofaciens | [115] |
Melanoma | 218 | ICB: αCTLA-4 mAb and αPD-1 mAb combined | Ruminococcaceae | Bacteroidaceae | [116] |
Advanced gastric cancer | 77 | ICB: αPD-1 mAb |  | Helicobacter pylori | [117] |
multiple myeloma (MM); acute lympholastic leukemia (ALL); non-Hodgkin lymphoma (NHL) | 78 | CAR-T | Faecalibacterium; Roseburia; Ruminococcus | Â | [118] |
Nasopharyngeal carcinoma (NPC) | 57 | ICB: αPD-1 mAb |  | Blautia wexlera; Blautia obeum; Erysipelatoclostridium; Ruminococcaceae bacterium; Ruminococcus sp. AF46-10NS | [119] |
HCC | 41 | ICB: αPD-1 mAb | Lachnoclostridium; Lachnospiraceae; Veillonella | Prevotella 9 | [120] |