Fig. 4From: Cholesterol-dependent amyloid β production: space for multifarious interactions between amyloid precursor protein, secretases, and cholesterolMembrane thickness and curvature affect the position of APP in the membrane. In thin or curved membranes, the C99/APP TM helices are more tilted than in thicker bilayers, which is associated with different types of dimerization and different γ-secretase-mediated processing. Adjusted according to [205, 206]Back to article page