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Fig. 6 | Cell & Bioscience

Fig. 6

From: Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

Fig. 6

FTO and ALKBH5 inhibits tumor growth in vivo. A Image of subcutaneous implantation tumors from FTO over-expression and ALKBH5 over-expression compared to Plvx groups. B, C Tumors were removed 4 weeks after subcutaneous implantation, followed by volume calculation and weight measurement. D–G Representative IHC staining images of Ki67/HK2/FOXO1 and quantification of Ki67/HK2/FOXO1 positive rate. H Western blot for HK2 and FOXO1 in FTO over-expression and ALKBH5 over-expression compared to Plvx groups in tumors. **p < 0.01; ***p < 0.001

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Cell & Bioscience

ISSN: 2045-3701

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