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Fig. 4 | Cell & Bioscience

Fig. 4

From: Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

Fig. 4

FTO and ALKBH5 restrains tumor progression via regulating HK2. A, B Volcano plots of the differential mRNA levels and m6A modification levels of FTO over-expression and ALKBH5 over-expression compared to Plvx groups by RNA-seq and MeRIP-seq. C, D The KEGG pathway enrichment in FTO over-expression and ALKBH5 over-expression is indicated by a bubble plot. E Venn diagram showed the overlap genes identified by RNA-seq and MeRIP-seq analysis. F The levels of HK2 mRNA were examined by RIP RT-PCR in HCT116 cells and SW620 cells. **p < 0.01; ***p < 0.001

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Cell & Bioscience

ISSN: 2045-3701

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