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Fig. 2 | Cell & Bioscience

Fig. 2

From: Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer

Fig. 2

Knockdown of FTO promotes proliferation, migration, and invasion of CRC A Knockdown of FTO by three different shRNAs in two CRC cell lines verified by western blot. B–G The results of CCK-8, colony formation, and EdU assays in FTO knockdown stably cell lines and control groups, together with its statistical chart (magnification times, 200 ×). H–J Transwell results of FTO knockdown in HCT116 and SW620 cells, together with its statistical chart (magnification times, 100 ×). **p < 0.01,***p < 0.001

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