Fig. 8

Schematic illustration of the roles of CrebH on IBD-induced liver injury. Bacteria and their products, cytokines, growth factors, and other factors move from the gut to liver through the blood stream during IBD. These contribute to liver injury via stimulation of inflammation. In normal condition, exosomal miRNA blocks the expression of MAdCAM-1 via regulation of TNF-R1. However, absence of CrebH lead to aberrant exosomal miRNA, resulting in severe liver injury