Fig. 1
From: Autophagy in the control and pathogenesis of parasitic infections
Cytosolic dsDNA induces STING-dependent and AIM2-dependent innate immune responses. STING regulates dsDNA-induced expression of type I IFNs and eliminates invading pathogen. Autophagy is involved in the STING-dependent antimicrobial response. STING-dependent IFN response is negatively regulated by Atg9a. Upon dsDNA stimulation, autophagy is induced in an AIM2-dependent manner and leads to degradation of activated AIM2-inflammasomes, which blocks the immune response