Table 1 Top 50 annotated genes with increased methylation
Rank | Symbol | Gene name | log2 Fold Change | Location | Type(s) |
|---|---|---|---|---|---|
1 | ZNF330 | zinc finger protein 330 | 4.614 | Nucleus | other |
2 | ACTR3B | ARP3 actin-related protein 3 homolog B (yeast) | 4.540 | Other | other |
3 | CAV3 | caveolin 3 | 4.292 | Plasma Membrane | enzyme |
4 | NKX2-3 | NK2 homeobox 3 | 4.199 | Nucleus | transcription regulator |
5 | TLN2 | talin 2 | 4.199 | Nucleus | other |
6 | CPD | carboxypeptidase D | 4.100 | Extracellular Space | peptidase |
7 | CTNNBL1 | catenin, beta like 1 | 4.100 | Nucleus | other |
8 | Vmn2r1 | vomeronasal 2, receptor 1 | 4.100 | Plasma Membrane | other |
9 | Cmtm2a | CKLF-like MARVEL transmembrane domain containing 2A | 3.993 | Cytoplasm | transcription regulator |
10 | HPS6 | Hermansky-Pudlak syndrome 6 | 3.993 | Cytoplasm | other |
11 | KANK1 | KN motif and ankyrin repeat domains 1 | 3.993 | Nucleus | transcription regulator |
12 | RRP1 | ribosomal RNA processing 1 | 3.993 | Nucleus | other |
13 | SNX10 | sorting nexin 10 | 3.993 | Cytoplasm | transporter |
14 | UNC93A | unc-93 homolog A (C. elegans) | 3.993 | Plasma Membrane | other |
15 | Zfp932 | zinc finger protein 932 | 3.993 | Nucleus | other |
16 | ANKRD13D | ankyrin repeat domain 13 family, member D | 3.877 | Plasma Membrane | other |
17 | DACT1 | dishevelled-binding antagonist of beta-catenin 1 | 3.877 | Cytoplasm | other |
18 | DMRT2 | doublesex and mab-3 related transcription factor 2 | 3.877 | Nucleus | other |
19 | DSC3 | desmocollin 3 | 3.877 | Plasma Membrane | other |
20 | LDOC1 | leucine zipper, down-regulated in cancer 1 | 3.877 | Nucleus | other |
21 | LRRC8B | leucine rich repeat containing 8 family, member B | 3.877 | Other | other |
22 | SEPP1 | selenoprotein P, plasma, 1 | 3.877 | Extracellular Space | other |
23 | SMAD3 | SMAD family member 3 | 3.877 | Nucleus | transcription regulator |
24 | Smok2a | sperm motility kinase 2B | 3.877 | Other | other |
25 | TCEAL3 | transcription elongation factor A (SII)-like 3 | 3.877 | Other | other |
26 | TNS1 | tensin 1 | 3.877 | Plasma Membrane | other |
27 | TRHR | thyrotropin-releasing hormone receptor | 3.877 | Plasma Membrane | G-protein coupled receptor |
28 | WWC1 | WW and C2 domain containing 1 | 3.877 | Cytoplasm | transcription regulator |
29 | PER2 | period circadian clock 2 | 3.853 | Nucleus | other |
30 | BHLHE23 | basic helix-loop-helix family, member e23 | 3.752 | Nucleus | transcription regulator |
31 | GALNT13 | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 13 (GalNAc-T13) | 3.752 | Cytoplasm | enzyme |
32 | KCNF1 | potassium voltage-gated channel, subfamily F, member 1 | 3.752 | Plasma Membrane | ion channel |
33 | MPP1 | membrane protein, palmitoylated 1, 55 kDa | 3.752 | Plasma Membrane | kinase |
34 | OPA1 | optic atrophy 1 (autosomal dominant) | 3.752 | Cytoplasm | enzyme |
35 | PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 3.752 | Cytoplasm | phosphatase |
36 | SGCZ | sarcoglycan, zeta | 3.752 | Plasma Membrane | other |
37 | ADCY7 | adenylate cyclase 7 | 3.614 | Plasma Membrane | enzyme |
38 | ALCAM | activated leukocyte cell adhesion molecule | 3.614 | Plasma Membrane | other |
39 | AR | androgen receptor | 3.614 | Nucleus | ligand-dependent nuclear receptor |
40 | C4orf33 | chromosome 4 open reading frame 33 | 3.614 | Other | other |
41 | CCNH | cyclin H | 3.614 | Nucleus | transcription regulator |
42 | CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 3.614 | Nucleus | kinase |
43 | CDV3 | CDV3 homolog (mouse) | 3.614 | Cytoplasm | other |
44 | COMT | catechol-O-methyltransferase | 3.614 | Cytoplasm | enzyme |
45 | CRYGC | crystallin, gamma C | 3.614 | Cytoplasm | other |
46 | FAM13A | family with sequence similarity 13, member A | 3.614 | Cytoplasm | other |
47 | IGF1R | insulin-like growth factor 1 receptor | 3.614 | Plasma Membrane | transmembrane receptor |
48 | IYD | iodotyrosine deiodinase | 3.614 | Plasma Membrane | enzyme |
49 | JAG1 | jagged 1 | 3.614 | Extracellular Space | growth factor |
50 | KCNMA1 | potassium large conductance calcium-activated channel, subfamily M, alpha member 1 | 3.614 | Plasma Membrane | ion channel |