Proliferative ductular reactions correlate with hepatic progenitor cell and predict recurrence in HCC patients after curative resection

Table 2 Immunohistochemical stain results and clinicopathologic features in peritumoral tissue of 120 HCCs

Clinicopathologic features	Peritumoral EpCAM density		P Value	Peritumral OV6 density		P Value	Peritumral CD133 density		P Value	Peritumral c-kit density		P Value
Clinicopathologic features	High	Low	P Value	High	Low	P Value	High	Low	P Value	High	Low	P Value
Frequency (%)	40 (33.3%)	80 (66.7%)		34 (28.3%)	86 (71.7%)		33 (27.5%)	87 (72.5%)		39 (32.5%)	81 (67.5%)
Gender
Male	35	73	0.747	30	78	0.946	30	78	1.000	37	71	0.363
Female	5	7		4	8		3	9		2	10
Age
≤50	21	42	1.000	16	47	0.453	19	44	0.493	20	43	0.853
>50	19	38		18	39		14	43		19	38
AFP
≤400	25	56	0..408	22	59	0.681	23	58	0.752	24	57	0.333
>400	15	24		12	27		10	29		15	24
Cirrhosis
Absence	20	51	0.149	19	52	0.645	17	54	0.294	17	54	0.016*
Presence	20	29		15	34		16	33		22	27
Satellite lesion
Absence	36	69	0.770	28	77	0.284	29	76	1.000	35	70	0.606
Presence	4	11		6	9		4	11		4	11
Tumor size (cm)
≤5cm	15	37	0.362	15	37	0.913	16	36	0.483	18	34	0.665
>5cm	25	43		19	49		17	51		21	47
Tumor encapsulation
Absence	26	61	0.193	26	61	0.540	23	64	0.672	27	60	0.578
Presence	14	19		8	25		10	23		12	21
Microvascular invasion
Absence	17	38	0.604	17	38	0.565	18	37	0.238	22	33	0.107
Presence	23	42		17	48		15	50		17	48
Major vascular invasion
Absence	39	75	0.657	33	81	0.853	29	85	0.083	38	76	0.687
Presence	1	5		1	5		4	2		1	5
Edmondson grade
Low (I/II)	27	63	0.180	21	69	0.035*	23	67	0.409	28	62	0.574
High (III/IV)	13	17		13	17		10	20		11	19
TNM stage
I/II	25	67	0.009*	23	69	0.142	16	76	<0.001*	29	63	0.678
III	15	13		11	17		17	11		10	18

ISSN: 2045-3701