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Figure 1 | Cell & Bioscience

Figure 1

From: Perturbations at the ribosomal genes loci are at the centre of cellular dysfunction and human disease

Figure 1

Proposed model of genome-wide consequences of rDNA instability. Under normal conditions rDNA copy number is maintained at uniform levels due to tight control of homologous recombination (HR) at rDNA loci. Induced HR in response to DNA damaging stimuli can lead to an increase or decrease in rDNA copy number resulting in an imbalance in the ratio of active to silent rDNA. This, in turn, will affect ribosome biogenesis independent functions of rDNA, which include regulation of heterochromatin content and DNA damage response leading to global genome instability and promoting aging or disease.

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Cell & Bioscience

ISSN: 2045-3701

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