Figure 1From: Histone H3K79 methyltransferase Dot1L is directly activated by thyroid hormone receptor during Xenopus metamorphosisMouse and Xenopus tropicalis DOT1L proteins are highly conserved. (A) Schematic alignment of mouse and Xenopus tropicalis DOT1L. The gray boxes represent conserved domains for S-adenosylmethionine (AdoMet or SAM)-dependent methyltransferases (AdoMet-MTases). The black boxes indicate structural maintenance of chromosome (SMC) domains. GenBank accession numbers: Mouse (m; Mus musculus) Dot1a (AAP42293) [50], Xenopus tropicalis (Xt) Dot1L (XP_002937984). Note that the N-terminal region is highly conserved between mouse and Xenopus tropicalis Dot1L due to the presence of the AdoMet-MTase and SMC domains. (B) The amino acid sequences of the nearly perfectly conserved AdoMet-MTase domain of mouse and Xenopus DOT1L. The AdoMet-binding site, which is essential for the methyltransferase activity, is boxed.Back to article page