Figure 1
From: A new chapter: hematopoietic stem cells are direct players in immunity
A model of the interplay between HSCs and the immune system. HSCs express surface immune molecules for "in" signaling and "out" signaling that directly dialog with the immune system. Whereas the "out" signaling, mediated by surface molecules such as CD47 and CD274, inhibits attack from the innate immunity and adaptive immunity responses, respectively, the stimulatory "in" signaling from inflammation activates HSCs and induces differentiation through surface receptors including TLR, TNFR, IFNR, and others.